Although increased H3K27me3 may reflect gene repression and silencing associated with LPS-triggered terminal differentiation, understanding the nature of decrements and the involvement of Jmjd3 in their occurrence requires a careful analysis.
and reflect repression of negative affect (Garssen and Remie, 2004; Myers and Derakshan, 2004).
The role of these startups is unknown, though they may reflect the general repression of components of the ES cell-specific self-renewal network by Trim28.
While BT10 shows stronger effects in the qPCR assays shown here, the relative differences in gene induction or repression may reflect both the different concentrations of the compounds used in the assay, but also receptor complex specificity.
They provide a stiff but effective reminder that in China's political system—"a people's democratic dictatorship"—it is the dictatorship bit that counts.This bout of repression, however, may reflect more than the usual cycle.
Both isoforms also induced upregulation in the expression of a significant number of targets, which may reflect indirect effects mediated by the repression of upstream regulators.
Overall the requirement for these multiple, non-redundant transcriptional repressors is striking and may reflect the importance of timely de-repression in response to genotoxic stress over robust down-regulation of MBF target genes once cells proceed through S-phase.
There was also a 2-fold increase in transcripts for the deacetylase Phf21a (GeneID: 192285), which may reflect the importance of this gene in the repression of neural genes in non-neural tissues [59].
These differences between types of cancers in the abundance of MBD2 levels may reflect different roles for MBD2 either in transcriptional repression or in the demethylation process.
The potent effect of HDAC inhibitors may reflect both derepression of epithelial genes and potentially indirect repression of mesenchymal genes (Jordaan et al., 2013, Mariadason et al., 2000, Gryder et al., 2012, Wagner et al., 2010).
