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Such decreases in receptor activity may reflect reduced ability to interact with biochemical effectors (e.g., the beta-adrenergic receptor, rhodopsin), reduced affinity for binding agonist ligands (EGF,IGF-I, insulin receptors) or reduced enzymatic activity (e.g., tyrosine kinase activity of the insulin or EGF receptor).
For instance, decreased levels may reflect reduced matrix degradation, decreased synthesis, or impaired release from the tissue or origin [33].
A strategy in which poorer nutritional conditions surface specifically when environmental conditions deteriorate, as shown here, may reflect reduced phenotypic plasticity resulting from poorer developmental conditions.
A downregulation of aquaporin 7 in hypoxic rats may reflect reduced glycerol transport as a consequence of a shift of the metabolism from fatty acids to carbohydrates.
Since AgRP is synthesised only in the ARC [25], [26], this finding may reflect reduced synthesis/transport or increased release of the peptide and/or disrupted development of the AgRP-containing projections from the ARC to the PVH.
However, the odds ratio confidence intervals for the latter two outcomes were unusually wide, which may reflect reduced power due to the small number of sarcopenic non-obese participants in the younger age group.
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Atkinson and his co-authors [ 29] suggested that complaints of dry mouth may not reflect reduced salivary function and may instead reflect dehydration or other systemic condition.
In the Rotterdam study [39], cerebral hypoperfusion was associated with a greater risk of dementia although reduced cerebral blood flow may simply reflect reduced demands of an atrophying brain.
This seasonality may be partially attributed to the washout effects and the shorter lifetime of SO2 in summer, but may also reflect reduced coverage by OMI due to increased cloud cover during the monsoon.
The relatively small genomes and few affinities may also reflect reduced interactions with eukaryotic hosts (as epiphytes, pathogens, etc).
The longer half-life of MM07 may therefore reflect reduced internalization as indicated by our in vitro assays.
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CEO of Professional Science Editing for Scientists @ prosciediting.com