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The aim of this study was to determine whether the higher susceptibility to coronary heart disease and diabetes in South Asian immigrants to the United Kingdom compared with the Caucasian population may reflect insulin resistance and altered postprandial lipid metabolism.
Persistent hyperglycemia may reflect insulin resistance.
The inflammatory process may reflect insulin resistance or its correlates but most likely is not causative.
Elevated plasma 1,5-AG in aged, fasted rats may reflect insulin resistance or dysfunctional renal handling of glucose.
These findings are not inconsistent because NAFLD may reflect insulin resistance, more so than MetS, in individuals without diabetes or obesity.
The very high blood glucose levels seen on day 3 or 4 may reflect insulin resistance secondary to high levels of growth hormone and the stress related hormones catecholamines and cortisol.
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However, cord-blood insulin levels may also reflect insulin sensitivity at birth.
The association between leptin and incident diabetes has been difficult to determine but may also reflect insulin resistance.
The differences during insulin infusion may reflect altered insulin sensitivity in skeletal muscle (glucose uptake) and adipose tissue (lipolysis).
Such changes may appear the increases of HOMA-IR and Matsuda Index, suggesting that these indices may not exactly reflect insulin sensitivity under liraglutide treatment.
This result indicates that the diabetes risk attributable to vitamin D insufficiency is mainly related to decreased insulin sensitivity rather than β-cell dysfunction in Koreans; thus, higher fasting serum insulin levels and HOMA2%B in the < 50-nmol/l 25OHD subgroups may reflect compensatory insulin secretion to overcome insulin resistance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com