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It has been shown that tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential anticancer agent that induces a greater level of necrosis-like cell death under acidic conditions than at physiological pH (Meurette et al, 2007), and this may reflect induction of caspase function (Lee et al, 2004; Meurette et al, 2005).
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The overlap of activities may also reflect induction of MGMT expression in methylated tumors in response to exposure to corticosteroids, as suggested by work of Weiler et al. [4].
Parks and Spradling [10] have proposed that specific spatial expression patterns of D. melanogaster chorion genes may reflect gene induction on different follicular cell populations.
Alternatively, this may reflect the induction by stress-related hormones (glucocorticoids) during metamorphosis.
These acute symptoms may reflect the induction of a state of acute peripheral nerve hyperexcitability detectable on electromyography (EMG) and other neurophysiological studies after oxaliplatin treatment [ 10- 12].
The focal nature of nuclear positivity may reflect the induction of this pathway in a subset of cells that has acquired new genetic or epigenetic changes that activate NF-κB and thus may activate downstream anti-apoptotic pathways.
33 The absence of changes in intracellular expression of other cytokines after 6 hours of stimulation, in contrast with their elevations as soluble forms at 48 hours, may reflect cascade induction.
Three of these genes, ICOS, SLAMF1 and CD53 encode proteins that play important roles in cell-cell signalling and the regulation of cell proliferation suggesting that they may reflect the induction of proliferation in the ConA activated PBLs [ 58].
The similarity of expression patterns among the Hsp20 proteins may reflect shared induction mechanisms, and possibly extensive coordination among Hsp20s as cellular chaperones, such as that observed during the formation of heat-stress granules [ 60].
The high expression of CASTOR and POLLUX genes in NI may suggest that at 21 DAI the plant is still attempting to establish SNF or may reflect the induction of Ca2+ channels by ROS as described in Pisum sativum [ 78, 79].
These behaviours after the onset of ataxia and the results may reflect a smoother induction to unconsciousness in analgised birds.
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