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We propose that the differentiation deficits of the SNCA_Tri NiPSCs observed in this study may reflect functional de-differentiation (loss of function) undergone by neurons affected in and by PD over an extended period of time, whereas compensatory and neuroregenerative processes in the brain impede or at least delay the development of overtly clinical disease.
Dhond RP, Yeh C, Park K, Kettner N, Napadow V. Previous studies have defined low-frequency, spatially consistent networks in resting fMRI data which may reflect functional connectivity.
Axons from the olfactory bulb form two main tracts, and these may reflect functional differences that in terrestrial vertebrates become separated as the olfactory and vomeronasal systems.
Here, we examined the hypothesis that the dissociation between pars opercularis and pars triangularis activation may reflect functional differences between clause-medial and clause-initial word order permutations, respectively.
Changes in the urine-only subproteome may reflect functional changes of the kidney directly.
Allometric shape changes in development may reflect functional changes and possible relationships between morphology and environment.
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These differences in Basic region conservation may indeed reflect functional differences.
If this is true, then differences in protein expression may largely reflect functional adaptations observed in species phenotypes.
However, measuring antibodies to recombinant merozoite proteins has significant limitations and antibody reactivity in these assays may not reflect functional activity.
Covariation may therefore reflect functional and/or structural constraints.
Therefore, the integration of all the ranked results may better reflect functional similarity.
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