Sentence examples for may reflect epigenetic from inspiring English sources

Age-related changes in DNA methylation occurring in blood leukocytes during early childhood may reflect epigenetic maturation.

It is of interest that RBL2 expression was reduced not only in retinoblastomas with 16q loss (N=4), but also showed a 2.2-fold decrease overall in group 1 retinoblastomas relative to group 2, which may reflect epigenetic regulation (De Falco and Giordano, 2006).

These differences may also reflect epigenetic variation among the clones.

Re-analysis of these samples, using DNA methylation patterns known to characterize individual leukocyte subtypes to deconvolve the global patterns observed, revealed that the effects of aging were almost wholly attributable to cell subtype composition, and may not reflect epigenetic changes in any of the cells studied [ 89].

This latter may reflect natural epigenetic variability amongst cell clones, since two other similar knockout clones (MALAT1_A KO2,3) show a weak reduction in RNA levels (Fig.  6a).

The particular enrichment of age-related hypermethylation in promoters that are annotated as "bivalent" might therefore reflect epigenetic changes in aging epidermal stem cells, and may underpin the decreased regenerative capacity of aging stem cells [ 39].

This may be the result of loss of GVG control of the transgene during transformation, or could reflect epigenetic interference.

These changes reflect epigenetic regulation.

Our data also suggest that these alterations may reflect underlying functional epigenetic alterations to genes important in placental growth and development.

Suppression of these proteins by the extract may reflect the underlying epigenetic mechanism that ultimately caused the reduced expression of all the mitochondrial and metabolic proteins and enzymes.

Although altered DNA methylation on several CpG islands has been reported separately in RCCs (26– 28), subclassification of clear cell RCCs, which may reflect the distinct epigenetic pathways of carcinogenesis, has never been established on the basis of genome-wide DNA methylation profiling.