This resistance may reflect the differentiated state of DC which, apart from IDC over the first 24 h, do not proliferate significantly following their initial culture period.
Keratinocytes have a higher number of both completely unmethylated and completely methylated CGs in comparison to the dermal fibroblasts, which may reflect the more differentiated state of the keratinocytes.
Therefore this in vitro EMT phenomenon may reflect histological change from differentiated to undifferentiated type during HCC progression.
This association may reflect an inability of less differentiated cancer cells to maintain an intact mevalonate pathway.
The increased AChE mRNA level in poorly differentiated HSNCC may reflect the cell attempts to increase catalytic AChE as a means to attenuate cholinergic over-activation.
E2f4 and E2f5 mRNA expression decreased in adult SC-RbKO testes that may reflect the loss of the differentiated haploid spermatids (Supplementary Figure S6).
Under this scenario, in replicated commercial populations that have been under similar breeding regime inter- and intrapopulations (e.g., egg layers vs. broilers), an overlapping cluster of differentiated alleles may reflect parallel divergence of beneficial allele.
We observed an increase in poorly differentiated DCIS that may reflect increased use of mammography and also could represent a downstaging from invasive to in situ cancers, as hypothesised (Sumner et al, 2007).
The observation that participants, randomly contacted according by RDD, demonstrated attitudes less differentiated than expected, may reflect their true status, given the limits of cognitive nuance on selected topics.
Of all cell types that are infected by HIV, the kinetic constraints placed on these cells are most consistent with infected monocytes, where the slow progression from RT to integration may reflect the long time to differentiation into macrophages, followed by rapid integration (occurring in differentiated macrophages).
