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This may reflect cartilage maturation [ 131].
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Such increases may also reflect cartilage degradation.
This study was done with conventional anteroposterior radiographs of the knee and evaluated overall changes in OA grade, and therefore the findings may not reflect cartilage loss.
Biomarkers of cartilage turnover may reflect structural cartilage changes and thus may identify patients at risk of early onset of OA (Rousseau and Delmas 2007).
Measurement of the C2C/CPII ratio may more closely reflect cartilage changes in RA through measurement of both the synthesis and destruction of type II collagen.
Greater levels of C2C-HUSA and CTX-II in adolescents than in adults may reflect increased cartilage turnover in response to higher joint loading.
Some types of biomarkers reflect cartilage degeneration, others reflect inflammation condition of synovium.
To test this hypothesis, we grouped biomarkers into those that potentially reflect cartilage synthesis (CPII) and those that reflect cartilage degradation (Col2 3/4Clong [Col2 3/4CshortCshort [C1,2C], and Col2CTx).
Streaming potentials reflect cartilage composition and function, and are sensitive to degradative changes.
Safranin O staining was used to reflect cartilage proteoglycan depletion during the development of experimental arthritis.
These results suggest that changes in cartilage matrix turnover detected by molecular biomarkers may reflect early changes in cartilage structure that account directly or indirectly for knee pain.
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