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This may reflect aggregation of tau monomers into aggregates of varying number, size, and single channel conductance.
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The slower migrating bands at high H-NS concentrations (≥10 µM) that appear prominently at 37°C and to some extent at lower temperatures may reflect either aggregation or restoration of bridging interactions.
The increased c-Src activity exhibited by pIRES-CEACAM6.1 and pIRES-CEACAM6.2 transfectants may reflect auto-aggregation of the GPI-linked protein within membrane lipid rafts, as occurs when other PGI-linked proteins are present at high density in the cell membrane.
IBs are the terminal stage of a series of aggregation steps, leading us to predict that IB morphology, lethality, and formation kinetics may reflect the preceding aggregation processes.
Most directly, mutations of the antioxidant superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis (ALS), although this may reflect effects on aggregation rather than oxidation state.
This may reflect the weak aggregation of (KW 5 in aqueous solution, which would reduce its electrostatic potential and therefore its antibacterial activity.
The effect of fly group size may reflect the role of aggregation pheromones, which act as communication signals between flies on breeding substrates, with feeding and oviposition rates increasing with the level of aggregation pheromone [28].
This may be explained by increased aggregation of tau at acidic pH and may reflect the kinetics of the aggregation process.
Given literature demonstrating that aberrant immune activation is observed in HD patient CSF even prior to onset of disease symptoms,40 our finding that patient CSF has aggregation enhancing activity may reflect multiple molecular characteristics of disease.
This result may reflect the YFP or overexpression-induced aggregation of YFP-STIM2 and ORAI1 constructs.
The accumulation and aggregation of α-synuclein in PD may reflect changes to its synthesis and/or degradation.
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