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It thus remained unclear whether sIL-2R may be universally useful to monitor inflammatory activities in progressing CLD and to which extent sIL-2R may reflect activation of distinct leukocyte subpopulations in CLD.
In addition, soluble CD146 (sCD146) may reflect activation of angiogenesis.
High levels of pErk may reflect activation of ras rather than EGFR, a condition where EGFR TKI would be ineffective.
Results obtained with [C]AMT under pathological conditions may reflect activation of the kynurenine pathway rather than 5-HT synthesis.
Correlation of sE-selectin and sP-selectin with lung function parameters in SSc patients may reflect activation of the lung endothelium in SSc lung disease.
S100A12 expression may reflect activation of neutrophils during pulmonary inflammation and may contribute to endothelial activation via binding to RAGE [ 26].
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Biomarkers downstream of PI3K/AKT/mTOR signaling may reflect pathway activation more accurately than activating mutations, since the effects of active signaling will be amplified across the entire tumor cell population through paracrine growth factor receptor pathways.
Furthermore, ATP release on the plasma membrane was correlated with CD11b expression, WBC counts, neutrophil counts, and CRP levels in sepsis patients; thus, ATP release on the plasma membrane may reflect PMN activation and could potentially serve as an activation marker for sepsis.
S100A12 expression may reflect neutrophil activation and contribute to pulmonary inflammation and endothelial activation via binding to RAGE [ 14, 18].
Circulating sCD40L is believed to derive predominantly from activated platelets and therefore may reflect platelet activation [ 10, 11].
Activation in the angular gyrus and precuneus/posterior cingulate regions (red in Fig. 4), on the other hand, may reflect incidental activation of semantic representations for words for which more semantic information happens to be available (e.g., high-frequency and/or high-imageability words).
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