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But Schurmans suggests that because SHIP2 seems to govern sensitivity to insulin, it's possible that some forms of the gene may reduce responsiveness to the hormone, causing the insulin resistance that is the hallmark of diabetes.
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Exogenous cannabinoids reduce responsiveness to noxious thermal, chemical and mechanical stimuli in rats.
Items with high missing values or ceiling/floor effects (>90% of the ratings in the highest vs. lowest response categories) were excluded from the subsequent analysis since they may reduce the sensitivity and responsiveness of the scale [ 28].
We have shown a significant decline in IL10 production by B cells in old donors upon LPS stimulation and a reduction in TLR4 expression on aged CD19+CD24hiCD38hi and CD19+CD5+CD1dhi B cells that may contribute to reduced responsiveness to LPS, which is also seen in monocytes and DCs with age (Qian et al., 2012).
This raises the hypothesis that although TGF-β overactivity may be a key to early SSc, reduced responsiveness may operate later.
Since this augmentation reflects the maximal SV and hence impacts the calculation of SPV, SVV and PPV, it may reduce their accuracy in predicting fluid responsiveness, especially when their values are in mid-range.
Studies suggest that a high loading dose of clopidogrel may reduce intra-individual variability and enhance responsiveness [ 14– 17], hence use of a clopidogrel 600 mg loading dose is widespread in clinical practice.
It should also be noted that long-term induction of autophagy may reduce cell viability by reducing the cells' responsiveness to stress [ 50].
Indeed, increased sensitivity to apoptosis as well as reduced responsiveness to glucocorticoids, may not only decrease the availability of T cells in depressed patients, but also may reduce their capacity to traffic to the brain in response to relevant neuroendocrine or immune stimuli.
Unfortunately transparency may reduce liquidity.
Alleviation of stress may reduce symptoms.
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