In addition, belatacept binds with similar affinity to CD80 and CD86, which may reduce selectivity for a particular type of cell activation as compared to a CD80- or CD86-selective tracer.
Similarly, because ranolazine blocks INaL in the ventricle, it has been suggested that the drug may reduce the occurrence of particular forms of ventricular arrhythmia involving prolonged repolarization and susceptibility to the development of helicoidal ventricular tachycardia.
Spread of such Prn-knock out strains may reduce vaccine efficacy, in particular of acellular vaccines which induce a less broad immunity than whole cell vaccines.
Vaccination, in particular, may reduce total population attack rates through increasing herd-immunity, but it is difficult to predict the impact of an imperfect pandemic vaccine on the transmission dynamics of a pandemic with characteristics that are still not fully defined [30], [31].
This delay may reduce the salience of these particular rewards.
In particular, it may reduce the probability that employers offer health insurance to employees (Emanuel 2014).
Traditional methods like bush hammering, polishing or flaming have various disadvantages that may reduce the market interest for particular applications.
One possible explanation for this result is that loss of a particular exoenzyme may reduce the bacterial invasive ability, permitting the host to mount a better defense.
Alternatively the effect may be indirect, for example phosphorylation of a particular site may reduce the transporters' cell surface expression, either by reducing trafficking to the plasma membrane, or by stimulating removal from the surface and possibly destruction in the proteasome.
In current smokers, we found that the consumption of vegetables and fruits combined and separately may reduce lung cancer risk, in particular the risk of squamous cell carcinoma.
