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Studies undertaken on NAFLD animal models suggested that probiotics may reduce liver inflammation and improve gut epithelial barrier function [ 13, 18].
Deletion of TIMP-1 may reduce liver fibrosis through abolishing the profibrogenic effect of TIMP-1, but may also accelerate liver fibrosis by increasing liver injury.
However, this is the first prospective study to report that physical activity may reduce liver cancer risk, suggesting that further study is called for.
As liver barrier may have an impact on the incidence of postoperative liver complications, we proposed the hypothesis that pre- and postoperative PRO may reduce liver permeability, decrease the rate of bacterial translocation (BT) and infectious complications after CLM surgery.
In addition, administration of a TIMP-1 antibody attenuated CCl4-induced liver fibrosis [ 15], thus we hypothesized that deletion of TIMP-1 may reduce liver fibrosis after chronic CCl4 exposure.
Beside, a study on a mouse model demonstrated that forced expression of Smad3 may reduce liver susceptibility to chemically-induced carcinogenesis by promoting apoptosis through Bcl-2 transcriptional repression [ 48].
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This means that even low levels of HBV treatment uptake may reduce liver-related morbidity.
Removal of a small part of the anatomical liver volume in a patient with cirrhosis may reduce the liver function relatively more than expected from the CT volume, which may lead to liver failure [6].
These observations imply that PP2Ac α may stimulate liver fibrosis via HSC activation and therefore its deletion may reduce the liver fibrosis through abolishing the profibrogenic effect of CCl4.
In addition, HCC patients usually require food restriction before surgery, which may reduce their liver steatosis.
Our research suggests that traditional Chinese medicines, such as SYY may provide potential candidates to reduce liver cirrhosis and prevent liver tumors.
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