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Another explanation is that probiotics may reduce gut inflammation, from whatever cause, in turn reducing associated infant distress.
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Thus, colloids may improve both systemic and intestinal perfusion and reduce gut ischemia [ 24- 26].
It has been suggested that limiting the bioaccessibility of nutrients may reduce the magnitude of gut hormone responses (37, 38).
Studies undertaken on NAFLD animal models suggested that probiotics may reduce liver inflammation and improve gut epithelial barrier function [ 13, 18].
The collective effects of these exposures, over time and following transmission from exposed mothers to infants, may reduce the diversity of the gut microbiota.
The bifidogenic properties of human milk are of particular interest, based on evidence that a bifidobacteria-predominant gut microbiota may reduce the risk of infections and allergies in infants [ 1- 4].
Bosentan may prove useful in reducing gut ischemia in septic shock conditions.
Dietary fiber may reduce estrogen reabsorption and deconjugation in the gut and thus protect against excessive estrogen supply [ 114].
PrRP may reduce food intake locally by modulating vago-vagal gut reflexes, but PrRP neurons also project to upstream targets in the hypothalamus (Dodd and Luckman, 2013).
Synbiotics may reduce VAP directly (reducing pathogenic organisms in the proximal gut) or indirectly (improving host immunity) [ 2].
There is evidence that both clay and starch exert some protective action against damage to the gut mucosa by proteolytic enzymes [98] and may reduce inflammation induced by antigens [44].
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