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Although many known regulatory mechanisms may reduce fluctuations in signals, most simultaneously influence their mean dynamics, leading to unfaithful cell fates.
In many cases one sample will not provide coverage of differentially expressed genes for the whole series, whereas pooling of samples may reduce fluctuations.
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A higher-order Legendre polynomial and, therefore, more orthogonal roots in each finite element may reduce these fluctuations.
This difference in the ability to reduce fluctuations may be of importance in the design of genetic networks.
However, extended release formulations that reduce fluctuations in plasma concentration may improve the forgiveness of once-daily drugs (Pellock and Brittain 2016; Chen et al. 2013; Brittain and Wheless 2015).
Compared with immediate-release (IR) antiepileptic drugs (AEDs), extended-release (XR) formulations reduce fluctuations in drug plasma concentrations, which may mitigate adverse events (AEs) caused by peak-dose toxicity or alleviate breakthrough seizures that can occur at trough concentrations.
The traces are additionally smoothed to reduce fluctuations.
But the decision not to prohibit indirect purchases, opponents argue, may have been intended to allow the ECB to carry out weekly repo operations, following a practice used by the Banque de France to reduce fluctuations in short-term interest rates.
We have previously shown that ICI does not induce major rearrangements in the structure of the monomer, but may reduce normal conformational fluctuations responsible for basal activity (Yao et al, 2006, 2009).
These respiratory and cardiac fluctuations may reduce the specificity of low frequency fluctuations to functional connected regions [66].
Cox et al. (20) found that high glucose variability precedes severe hypoglycemia, suggesting that reducing glucose fluctuations may reduce the risk for severe hypoglycemia.
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