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However, other mechanisms may reduce brain tissue oxygenation.

Run by London's Air Ambulance, it gets its name from the innovative system it carries to cool patients down, which may reduce brain damage after cardiac arrest.

Therefore, so-called "intensive" blood glucose control with the use of insulin therapy may reduce brain glucose availability and potentially increase energy dysfunction or aggravate metabolic distress [63, 65 67].

Decreased neuronal density seen in patients taking haloperidol is in agreement with pieces of evidence that antipsychotics may reduce brain tissue volume [ 55].

Therefore, so-called "intensive" blood glucose control with the use of insulin therapy may reduce brain glucose availability and potentially increase energy dysfunction or aggravate metabolic distress [ 63, 65- 67].

It is important to remark that the elevation of COX-2 has been already found in neurodegenerative disorders including HD, having an instrumental role in the pathogenesis, so that its reduction through different strategies (e.g., pharmacological inhibition) may reduce brain damage.

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It is still controversial that intrapartum exposure to magnesium may or may not reduce brain damage in premature infants in human and animal models.

Many nootropics like noopept may help facilitate Nerve Growth Factors but there are other natural supplements like Lion's Mane Mushroom which also may help reduce brain aging and free radical damage to brain cells.

The mechanism is unclear, but cooling may help reduce brain inflammation.

It is therefore important to identify inhibitory drugs of laminin-dependent AQP4 clustering which may prevent or reduce brain edema.

Sleep is not critically involved in this glucose-glucocorticoid feedback loop but may reduce the brain's sensitivity to the anorexigenic effect of enhanced glucose supply.

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