While SOCS family members use the SH2 domain to recruit substrates, the ANK repeat regions of Asb family members serve as specific protein-protein interaction platforms to recruit target substrates in different biological processes [ 1].
Transmembrane protein Atg9 may recruit lipid to phagophores38.
Alternatively, H3K36me may recruit Ku indirectly through other chromatin factors.
You may recruit some bodyguards, for your own safety".
It selectively recruits substrates for their ubiquitination and subsequent degradation.
KLHL3 is the substrate-recognition subunit of the ubiquitin ligase complex, recruiting substrates for ubiquitylation via its associated Kelch domain [ 17– 17].
They may either recruit novel substrates to their cytoplasmic domains or inhibit other inhibitory receptors (Redelinghuys and Brown, 2011).
Cereblon is proposed to function as a substrate receptor by recruiting substrate proteins to the CRL4 complex for ubiquitination (Lopez-Girona et al, 2012).
These studies provide a molecular understanding of how MATH-BTB proteins recruit substrates to Cul3 and how their dimerization and conformational variability may facilitate avid interactions with diverse substrates.
Mycobacterium tuberculosis harbors proteasomes that recruit substrates for degradation through an ubiquitin-like modification pathway.
