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CONCLUSIONS: Increased sensitivity of IMxBCM, despite a high correlation with CA15-3, suggesthathat IMxBCM and CA15-3 may recognize distinct epitopes on the same molecule.
The multiple AO isoforms are expressed tissue-specifically [4], [7], and may recognize distinct substrates and carry out different physiological tasks.
21 Thus, T and B cells may recognize distinct epitopes of the same autoantigen.
Many tumor markers exist in biological fluid as a family of isoforms and antibodies from different assays may recognize distinct subsets of this family.
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In contrast, low-resolution negative stain reconstructions of the recently isolated human survivor mAb, ADI-15946, suggest that it may recognize a distinct footprint in the base region of GP, crosslinking the GP1 and GP2 subunits20.
The fact that these 14-spanner transporters of the Major Facilitator Superfamily are hypothesized to recognize distinct substrates and may have different subcellular localization, at the plasma membrane, the vacuole membrane, post-Golgi vesicles and late endosomal vesicles [ 14, 18, 19, 71], suggests that it is unlikely that their sequence similarity may result from convergent evolution.
Since CLRs recognize distinct carbohydrates expressed on pathogens, the use of carbohydrates that are preferentially recognized by CLRs as targeting signals may provide a more sophisticated alternative, and carbohydrate-coated liposomes with encapsulated antigens may be a more suitable antigen delivery vehicle to target CLRs than antibodies.
Aristotle's refusal to recognize distinct senses of being led him into difficulties.
The bats can recognize distinct individuals and remember past events.
Different TLRs recognize distinct classes of products synthesized by pathogens.
In the case of TLRs, for instance, the same receptor in distinct species may recognize different ligands or the same ligand with different affinity (Werling et al. 2009).
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