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We also tested AbSV cyclic, which may recognize conformational epitopes among Opa proteins compared to AbSV linear.
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Alternatively, the linear 4L peptide may not induce antibodies that recognize conformational epitopes present in the native protein.
However, these protein regions may not represent epitopes for infection-induced antibodies, as most antibodies recognize conformational epitopes presented in the three-dimensional shape of the protein [ 37], and, even if cross-reactive antibodies were present, it would not prove causation of disease.
Since β1AR autoantibodies recognize conformational epitopes, they are thought to modulate receptor conformation or influence the stability of transient conformational states induced by true ligands.
Nine of the antibodies recognize conformational epitopes within HCV E2.
All our gH/gL-specific mAbs recognize conformational epitopes on MuHV-4-infected cells.
Finally, our analyses demonstrate that PNP anti-A2ML1 autoantibodies recognize conformational epitopes, explaining the two-decade failure to detect p170 by Western blot under denaturing conditions [7].
These are soluble proteins that recognize conformational features of the receptors and phosphorylated residues.
Given its immunogen characteristic, we speculated that it might also recognize conformational epitopes.
Whilst most potent and broad neutralizing antibodies recognize conformational epitopes a limited number have been shown to bind linear epitopes.
IgE antibodies are believed to mostly recognize conformational epitopes that depend on an intact protein structure [ 12].
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