Dike orientations within one of these early Miocene volcanoes and evidence for the existence of as much as 500 m of paleo-topography prior to widespread deposition of the Steens basalts at ∼ 16 Ma suggests that late Miocene faults near Lake Abert may reactivate an older structural fabric.
We model the reversion of productively infected cells to latency at a rate proportional to α R, while latently infected cells may reactivate at a rate proportional to α Q. Productively infected and latently infected cells each have intrinsic death rates represented by d P, and d L, respectively.
In addition, latent CMV may reactivate in a CMV positive recipient.
In some subjects, due to concomitant infections, malnutrition or other factors, latent M. tuberculosis may reactivate causing a post-primary TB that usually develops chronically, unless treated with antibiotics [ 6, 7].
It has been suggested that the human immune modulation gene down regulates the response to a sustained viral presence, and that disabling this gene may reactivate aggressive immune reactivity that could control the progression to AIDS.
Moreover, a recent report indicates that the RD cell line, derived from an embryonal RMS local recurrence and thus representative of an aggressive tumor [ 38], may reactivate muscle-specific genes and develop a partial recovery of myocyte phenotype following EZH2 knockdown when depleted of serum [ 26].
Furthermore, previous viral infections such as CMV may reactivate during the first few months in an immunocompromised post-engraftment individual.
"By going deeper we may reactivate the possibility that smallpox could become again a disease of humans in modern times".
These results suggest a possible mechanism whereby natalizumab treatment may reactivate latent viruses of the CNS (such as HHV-6) that can subsequently induce the replication of other viruses (such as JCV) that have been associated with catastrophic outcomes (PML) in a small subset of patients.
The occurrence of T cell activation may reactivate viral genome in the T cells leading to an immune response against the virus.
