As inferred by alignment to shorter homologous proteins encoded by either related species, or strains of the same species, most REPs located within the 5′ end of P. putida, C. koseri and S. maltophilia ORFs may be not codogenic, but rather function as post-transcriptional control elements.
Consequently, Rab25 may not play a role in tumour initiation either as a primary oncogene or tumour suppressor gene, but rather may function as a regulator of tumour progression in already transformed cells.
Although uncoupling protein-1 is a key mediator of thermogenesis in activated brown fat, the more recently characterized uncoupling proteins-2 and -3 do not appear to influence basal metabolism, but rather may function to diminish excessive mitochondrial superoxide production when mitochondrial redox potential is high.
We found no interaction between puf-8 and the Notch signaling pathway in either of these contexts (Table S2), suggesting that puf-8 is not a general negative regulator of Notch signaling but rather may function specifically in the germline to negatively regulate GLP-1/Notch signaling or function in parallel to the GLP-1/Notch signaling pathway to inhibit the proliferative fate.
The effects seen in mitochondrial function in sepsis may rather be a result of intracellular processes and signaling, such as e.g., production of reactive oxygen species.
PrPSc neurotoxicity may rather involve some toxic gain of PrPC function.
Rather, Eco1 may function as a more general factor that promotes cohesin ring opening or its turnover on DNA.
Some of them may rather be a description of the patients' severe multimorbid condition rather than the cause for a decline in renal function.
It may, rather, be something more systemic.
Similarly, for arboreal species, one could reasonably expect that any potential communicatory function may be rather related to olfactory signals obtainable from arboreally deposited urine than from terrestrial accumulation of feces, which may rather be a byproduct of localized urine marking.
