The current study indicates that TFV gel does not interfere with soluble mucosal immunity, a biomarker of safety, and that measurement of anti-HIV activity and drug levels in CVL may provide simple and inexpensive assays of PD (drug activity) and PK (drug distribution and clearance) near or at the site of drug action.
With refinement, one or both of the markers suggested by this study may provide simple means to quantify susceptibility to cervical cancer without HLA typing.
Rather, our goal was to examine the utility and prognostic significance of two different interpretations of a currently well-established frailty measure - elements of which may provide simple and practical screening tools for clinical purposes [ 19, 32].
Although the factors driving the higher inflammatory set-point in individuals predicted to develop early incident neuropathic symptoms is unknown, careful attention to micro-nutritional status and concomitant drug usage prior to starting cART may provide simple measures to reduce cellular oxidative stress known to augment inflammation.
Our "chunking-through-averaging" premise may provide a simpler, and perhaps unifying, position to this debate.
Distal tip cell migration, analyzed here, may provide a simpler model for Pak pathway relationships.
Also, using a novel technique such as DTM may provide a simpler and more accessible point of care testing for vascular reactivity in a perioperative setting.
Dabigatran and edoxaban do not require any dose alterations in the first weeks of therapy and may provide a simpler approach after patient discharge, but the need for a minimum of 5 days of injectable therapy may not be desirable.
Age dependent susceptibility to infection has been put forward, but differential dietary exposure to contaminated food products in the UK population according to age and sex during the bovine spongiform encephalopathy (BSE) epidemic may provide a simpler explanation.
Although they may provide the simplest practical response for an overwhelmed Veterans Administration system, psychotherapy is usually crucial in helping P.T.S.D. patients process their emotional reactions to traumatic events, put the trauma in perspective, and reach out for support.
