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Interestingly, increased hsa-miR-203 methylation was detectable in scrapes of women with high-grade CIN, indicating that methylated miRNAs may provide putative markers to assess the presence of precancerous lesions.
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The demonstration of increased mucosal nerve fibres immunoreactive to TRPV1 in human colonic biopsies from IBS patients, and their correlation with the degree of abdominal pain, may provide a putative basis of IBS symptoms.
These observations may contribute to our understanding of HPV pathogenesis and cervical carcinogenesis, and provide putative biomarkers for future patient care.
Re-sequencing of relevant variants of the TGFB2 gene may provide further information on putative functional polymorphisms explanatory of the role of TGFB2 in CM pathogenesis.
These possibilities need to be explored further in the future, and may provide stronger justification for putative preventive interventions.
Identifying pathology specific proteins with functions in key cellular processes may provide help to prioritize putative therapeutic targets.
In addition, the identification of zebrafish metzincin orthologues may provide insights into the putative third whole genome duplication event, proposed to have occurred within the actinopterygian lineage [ 37].
Comparing the neuropsychological functioning between the BD I and BD II types of depression may provide indications of these putative different entities.
The genotype-specific modulated transcripts are of particular interest for the present work as their annotation may provide clues to the putative mechanism of heat tolerance.
These data have been generated from wet lab experiments including Chromatin ImmunoPrecipitation Sequencing (ChIP-Seq), DNase hypersensitivity and histone modification studies, and thus may provide better evidence of putative function compared with predictive algorithms used previously to infer function at a locus.
Although initial identification of proteins via sequence similarities does not yield a clear indication of their respective functions, analysis of specific conserved regions and residues may provide important information regarding their putative functional characteristics.
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