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Other alterations also previously described in GBM, which may provide pathways alternative or complementary to epigenomic dysregulation, included PTEN mutations (two samples) which overlapped with H3.3 K27M while EGFR mutation or amplification (three samples) and CDKN2A mutation/loss (five samples) partially overlapped with SETD2 mutations (Table S1).
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Therefore, the identification of novel genes modulated by HDACi in colon cancer cells may provide pathway-driven rationale for novel and urgently needed efficacious drug combinations.
Floating vegetation (following a cyclone) may occasionally provide pathways for mouse lemurs, allowing them to cross these narrow rivers, as anecdotal evidence suggests.
In the cap rock, fractures may provide unwanted pathways for reservoir or stimulation fluids.
Sediment cracks and faults along with basement faults may provide necessary pathways for fluid transport and may play a vital role in hydration below the sediment column.
Furthermore, the complex structural geology has likely caused strong heterogeneities, e.g. along deep-seated faults that may provide preferred pathways for fluids and thus have locally strong effects on cementation and porosity.
If convulsants have a similar action in mammalian cortex, enhanced transmission at weak electrical synapses may provide abnormal pathways for the flow of seizure activity and contribute in part to the synchronous firing of neurons characteristic of epileptic activity.
Thus chemical modifications may provide alternative pathways for the rational design of peptides with applications in anti-tumor specific immunotherapy and in vaccine development.
The choice of formulation, design, and system components may provide potential pathways to optimize drug delivery and minimize residual drug.
Non-disclosure of HIV status has previously been shown to affect adherence [ 27], while having children may provide earlier pathways to care through antenatal screening [ 28].
As discussed below, the sequences underneath the peaks presented a very heterogeneous picture, indicating that different transcription factors may provide alternative pathways for recruiting Rbf1.
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