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Repeated loss of coding sequences of genes may provide parallel changes in protein function or protein protein interactions (e.g., truncation of C-terminal transactivation domain in meis/hth proteins, Irimia et al. 2011; and loss of Snag domains in C2H2 zinc fingers, Barrallo-Gimeno and Nieto 2009; Irimia et al. 2010).
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Reversible oxidation of Met to MetSO at the protein surface also occurs (29) and may provide a parallel redox network.
We know there is transependymal CSF absorption in hydrocephalus [ 28] and this may provide a parallel pathway.
City officials said that because patient deaths are often attributed to the primary illness rather than complications like hospital-acquired infections that may have pushed the patient over the brink, they could not provide parallel local statistics.
The rabbit HEV infection of rabbits may provide an appropriate parallel animal model to study HEV pathogenesis.
Fluidic systems to simultaneously isolate and analyze millions of cells in parallel may provide a comprehensive view of cancer development and response to therapy within each patient.
The activation of this parallel pathway may provide alternative proliferation and survival stimuli to cancer cells, even in the presence of inhibition in the ER pathway.
An in-depth understanding of these genomic regions, for instance by defining the selected phenotype and underlying mutations, may provide concrete evidences for explaining parallel adaptation to different selection regimes.
The proposed method may provide a promising platform for ECL parallel detection of small molecules and protein.
We hypothesize that variant allele fraction (VAF) data derived from massively parallel sequencing studies may provide further insights into the clonal architecture and pathogenesis of NPM1-driven leukemogenesis.
Parallel translational research may provide a better understanding of the mechanism of action of metformin in cancer and may reveal biomarkers predictive of response to metformin.
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