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Intranasal insulin administration appears safe, does not affect systemic glucose control, and may provide acute improvements of cognitive function in patients with type 2 DM, potentially through vasoreactivity mechanisms.
This study provides preliminary evidence that intranasal insulin administration appears safe in older adults with type 2 DM, does not affect systemic glucose control, and may provide acute improvements in cognitive function in older nondemented DM and non-DM patients.
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Norleucine may provide an acute strategy to control αKIC levels and prevent cerebral oedema during catabolic crisis.
But cannabinoids may do more than simply provide acute symptom relief.
Further translation of peritoneal oxygenation with OMBs may provide therapy for acute respiratory distress syndrome arising from trauma, sepsis, pneumonia, aspiration, burns and other pulmonary diseases.
Proteins in urinary EVs may provide biomarkers of acute kidney injury; for example, fetuitin-A in urinary EVs may be useful in diagnosing structural renal injury [32, 33], and decrease in the level of podocalyxin-like protein 1 (PODXL) in urinary EVs may provide a biomarker to classify renal disease [34].
Plasma exchange (or plasmapheresis), the removal of plasma proteins such as antibodies and replacement with normal plasma, may provide improvement in acute severe weakness.
The physico-chemical parameter Kow is of minor value to predict increased ACRs or to address uncertainties of this approach, while the acute toxicity level may provide options for refinement of acute-to-chronic extrapolation.
In this respect, altitude natives provide a reference for chronic altitude adaptation, and may provide additional insight into acute responses to altered oxygen availability.
Interestingly, COX2 is an important drug target, and suggests that commonly used COX2 inhibitors may provide a target for acute leukemia.
Trials of acute treatment may provide only a rough estimate of the benefits of contemporary acute treatment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com