Our study revealing variation of immune-associated genes in chromosome 17 and 18 gave an additional support to the essential role of TCs in immune surveillance and immune homeostasis which may protect from immune disorder in acute and chronic pulmonary diseases.
We have described the proposed roles of TCs in immune surveillance/tissue homeostasis which may protect from immune disorder in acute and chronic pulmonary diseases.
This body of work led us to the hypothesis that the release of psychological stress via emotional expression may protect the immune system (RF- patients).
They are able to protect immune therapeutic molecules like CpG ODNs from degradation.
Immune system may protect against cancer progression supported by our finding that innate immune system is impaired in metastasizing tumors.
As Bcl-2 overexpression may protect malignant cells from antitumour immune responses, we investigated whether coexposure to both Bcl-2 inhibitor and activated immune cells could increase tumour-cell killing.
On the other hand, the activation of the classical and lectin pathways may protect the vessels by removing immune complexes, cell debris, and apoptotic cells (6).
Downregulation of miR-125a in children with mild and moderate disease may thus represent reduced macrophage activation and inhibited NF-κB signaling, which may protect against an excessive innate immune response with a more severe disease phenotype.
Meng et al. found that LPA may protect epithelial ovarian cancer from immune cell attack and cytoskeleton disrupting reagents induced apoptosis through multiple pathways and LPA inhibited anti-Fas-induced apoptosis enhanced by actin depolymerization [ 26, 27].
Such a decreased immune response may protect from hemorrhage during dengue fever, 17 from lung cavitation, 20 from fever during tuberculosis, 25 and from lung injury during severe acute respiratory syndrome 29, 30 as a result of less cytokine production and diminished activation of immune cells.
