Cerebral microhemorrhages (CMHs) are associated with rupture of small intracerebral vessels and are thought to progressively impair neuronal function.
Additionally, we cannot exclude the possibility that ADMA might progressively impair β-cell function, another contributor to the development of type 2 diabetes [ 6- 9].
Calcineurin phosphatase inhibitors remain the mainstay of many antirejection regimens, and the agents are well known to progressively impair renal function.
This suggests that in later stage diabetes, when the actions of NO and PGI2 are progressively impaired [ 37], the coronary circulation may become more vulnerable to constrictions.
The National Aphasia Association describes primary progressive aphasia as a neurological syndrome in which language capabilities become slowly and progressively impaired.
Cenci, S. et al. Progressively impaired proteasomal capacity during terminal plasma cell differentiation.
The disease attacks the brain and spinal cord, progressively impairing actions like walking, swallowing and using chopsticks.
The capacity of the kidney to adjust to variation in intake of salt, potassium, and water becomes progressively impaired, so that electrolyte disturbances are common.
CD4+ T cells regulate humoral and cell-mediated immune responses, which are progressively impaired in aging, resulting in susceptibility to infections and cancer.
In clear contrast, cardiac function was progressively impaired in Bmx/CA mice compared with Ctrl mice (Fig. 2b,c, Supplementary Table 1), resulting in nearly 100% mortality at 60 weeks of age (50 weeks after TAM treatment) (Fig. 2d).
