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However, in patients with chronic reactive arthritis and HLA B27 the axial changes may progress to changes somewhat similar to those seen in AS and can then be regarded as AS elicited by infection [10].
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Hypoglycaemia results in neuroglycopenia, which causes cognitive impairment and mood change and may progress to behavioural changes, reduced consciousness, seizure and coma [ 3, 4].
These reactions include the serotonin syndrome, which includes the following signs: hyperthermia, rigidity, myoclonus, autonomic instability, and mental status changes that may progress to delirium or coma.
The haemodynamic changes that occur with chronic anaemia, renal hypoxia that results from recurrent vaso-occlusion and haemolysis-related endothelial dysfunction can lead to functional and structural changes which may progress to CKD [ 8, 10- 12].
These changes can resolve or may progress to fibrosis, traction bronchiectasis and focal honey combing.
Hemodynamic changes due to TCR may be persistent, may progress to ventricular arrhythmia, and may in some cases be severe enough to necessitate cardiopulmonary resuscitation [ 21].
These changes are dynamic; it has been reported that patients with preserved ventricular function may progress to develop severely depressed contractility [12].
If left untreated, it may progress to mycotic aneurysm [5].
This may progress to degenerative spondylolysthesis and require spinal instrumentation.
It has several presentations and may progress to severe illness.
These may progress to multiple organ failure.
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