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Because of the time required to establish an antitumor immune response, it can take longer for a detectable response to evolve with ipilimumab compared to cytotoxic agents, during which time the disease may progress or appear to progress.
Once having acquired its independence, the tumor may progress or not by successive additional steps to acquire all the hallmarks of cancers and to develop the competitiveness of its cells [ 116].
Similarly, bone biomarker assays may reflect alterations in bone metabolism that are present at the time the sample was collected, whereas the BML lesion seen on an MRI reflects a structural change that took place at some time in the past and may be stable, may progress, or may even regress.
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Depending on the location and cell type, brain cancers may progress rapidly or slowly over a period of many years.
Alternatively, LPD may progress, recur or (rarely) undergo malignant transformation [ 8].
Although more than 60% of patients survive without HSCT [3], it will be important to follow patients carefully, as this group manifested as lymphoma or dysgammaglobulinemia may progress to HLH or FIM in clinical course.
These neurological signs may appear within weeks or months after initial CDV exposure and may progress to death or cause permanent injury to the brain.
Long-standing mucus plugging may progress to linear or nodular calcification (Fig. 9).
However, mild headaches may progress to moderate or severe migraine attacks, and there is evidence showing that mild intensity headaches in migraineurs are of the spectrum of migraine.
Children with primary infection may progress to disease or move into the latent infection state.
When treatment is stopped, even temporarily, an HIV-positive person will be at higher risk of developing drug resistance, may progress to AIDS or die.
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