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These interactions may prevent substrate recognition by the proteasome.
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Specifically, as nucleosomal DNA is unraveled from the octamer, these interactions may serve to prevent substrate disassembly.
This approach allows us to reduce sample exposure to oxygen, which may be useful to prevent substrate oxidization in coated conductor fabrication.
In contrast, a soft and readily deformable type-1 collagen substrate may have prevented substrate induced myofibroblast differentiation and allowed for more sensitive detection of the original changes in gene expression that more closely reflect the tissues of origin.
However, debonding of FRP lamina from the substrate may prevent the achievement of the full load bearing capacity of the reinforced element.
If the BP is too big compared to the target CP, the atoms or molecules released by the BP when it fragments after collision with the CPs or the substrate may prevent the CP from leaving the surface [11]; this implies that BPs must be less than some maximum size if they are to effectively remove nanometer-size CPs.
Closure may form important interactions between the enzyme and substrate but also may prevent adventitious side reactions by excluding water from the active site or restricting release of reactive intermediates (as briefly described for AlkB above).
This aspect represents a critical factor with respect to the stone treatment as it may prevent the penetration of a product within the substrate.
Furthermore, the smaller particle thickness formed more sealed chambers, which may prevent the overflow of ethanol from the solid substrate.
Thus the phosphates in the tail could occupy that site and prevent substrates from binding.
However, debonding of FRP lamina from the substrate, made of either concrete or steel, may prevent the achievement of the full load bearing capacity of the reinforced element.
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