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This model suggests that steric hindrance may prevent simultaneous binding of BCL2L1 (or BCL2) and MK2 to Beclin 1, thereby inhibiting MK2-dependent Beclin 1 S90 phosphorylation.
(B ) Structural model showing that steric hindrance may prevent simultaneous binding of BCL2/BCL2L1 and MK2 to Beclin 1. MK2 (residues 44 216, 236 284 and 288 345), BCL2L1 (residues 2 25 and 83 198) and Beclin 1 (residues 79 181) are shown in cyan, pink and grey ribbon, respectively.
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