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Thus, if mutations occur sequentially, the shape of the fitness landscape may prevent evolution of the optimal phenotype [7, 8] offering a possible explanation for the poor discrimination of receptors found in nature.
In addition to having a more favorable toxicity profile than HU and IFN, PEG-IFN treatment has been associated with high rates of hematologic and molecular responses that may prevent evolution to MF and AML.
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[ 28, 29] In our patient population, a group exposed to extreme biomechanical stresses and predisposed to osseous stress injury, identification of osseous injury early in the disease process may help to prevent evolution to fracture and ultimately articular collapse or arthropathy.
Further reductions in pneumococcal carriage and increased prevention of early AOM infections may prevent the evolution of severe, complicated AOM.
Further reduction of pneumococcal carriage and early AOM infections may prevent the evolution of severe, complicated AOM.
Clinical implications and strategies that may prevent the evolution of resistance or target the origins of genetic heterogeneity are discussed.
This may prevent the evolution of a tissue 'oxygen debt' and hence reduce the incidence of complications and organ dysfunction [ 19].
Therefore, although the benefit of having thicker pericarps is still significant in Kawahara (Table 3), considerable costs of resource allocation to pericarps may prevent further evolution (Tables 4 and 5).
Forrest and Thomson (2009) argued that pollen limitation may prevent the evolution of flowering plant phenology when pollinator foraging is frequency dependent and pollinator phenology is constant, and suggested that this might lead to the extirpation of flowering plant populations under strong selection.
A lack of suitable clinical material prevented full evaluation of the pathogenic potential of R. aeschlimannii in this patient and prompt antibiotic intervention may have prevented evolution of the syndrome.
Thus, genomic heterogeneity may be an attractive therapeutic target to prevent evolution of more aggressive or resistant clones.
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