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Recently, Abe et al 22 reported that accelerometer determined ambulatory activity, especially moderate and vigorous intensities (>3 METs), is positively correlated with the tibialis anterior (r = 0.34, P < 0.05), as well as by the triceps surae muscle thickness (r = 0.41, P < 0.01), suggesting that >3 METs of physical activity may prevent age related loss of muscle mass in the lower leg muscles.
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Long-term studies in primates are finding that cutting calories may prevent age-related diseases such as atherosclerosis, but it's not yet clear whether such a diet helps them live longer.
Preserving PGC-1α activity in the SNpc may prevent age-related alterations underlying neuronal vulnerability in PD.
Here we investigated whether treatment with low doses of rapamycin given in food may prevent age-related brain pathology in OXY rats.
The nNOS transgene prevented age-related increases in arginase-1 but did not influence TGFβ expression, indicating that the transgene may prevent age-related muscle fibrosis by inhibiting the arginase-dependent profibrotic pathway.
Finally, a study in Rhesus macaques found that age and DR alter the plasma metabolome and may prevent age-related changes in the metabolome (see Table 3 in Rezzi et al., 2009).
Here, we asked whether suppression of IGF-I receptor (IGF-1R) in adult stem cells preserves long-term cell replacement, and whether this may prevent age-related functional decline in a regenerating tissue.
Besides, carotenoids with unsubstituted β-ionone rings, such as β-carotene, have provitamin A activity [ 16] while other carotenoids such as lutein may prevent age-related macular degradation [ 17, 18].
Fourth, targeting these pathways may prevent aging and cellular senescence.
On the contrary, increased level of mitochondrial biogenesis may prevent aging [ 4].
Studies have shown that lutein, a nutrient abundant in spinach, may prevent age-related macular degeneration and cataracts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com