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In conclusion, based on the significant association between DNA and nucleosomes, DNA may predominantly circulate in form of nucleosomes in human blood.
Our detection of the significant association of nucleosome concentrations with DNA concentrations in blood of all patients and healthy individuals emphasized that DNA may predominantly circulate in form of nucleosomes in human blood.
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In healthy lean individuals, liver NNMT activity may predominantly determine circulating MNA levels.
Our results may not reflect the predominantly circulating strains of M tuberculosis in the general population.
Switching of the predominantly circulating subtype (HRSV) or genotype (HMPV) may be a result of fluctuating circulating frequencies of contemporary clades, which cycle through proliferative and eclipse phases, and is not due to novel lineage emergence events.
An explanation of this incongruence might be in the differences between the predominantly circulating lineages of the UK and Belgium; these may differentially evolve and/or be under dissimilar structural or immunologic constraints.
The predominantly circulating genotype among study patients is genotype 2a.
Here, we aimed to evaluate the antiviral activity of these peptides against HIV-1 subtypes predominantly circulating in China.
For the inter-subtype diversity analysis, we used subtypes B and C and a circulating recombinant CRF01_AE as reference strains that are predominantly circulating in Asian countries.
Switching of the predominantly circulating genotype (HMPV /subtype (HRSV) therefore cannot be attributed to the emergence of novel virus lineages.
All the other 10 Indian isolates belonged to clade 7 which has been the predominantly circulating clade since week 9 in Asia [11].
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