For example, CSSA scores may predict response to treatment with the anticonvulsant drug topiramate.
Serum Hepatitis B surface Antigen (HBsAg) levels correlate with hepatitis B virus intrahepatic covalently closed circular DNA and may predict response to treatment.
The NCI Molecular Analysis for Therapy Choice (MATCH) trial [NCT02465060] which screens for molecular features that may predict response to a drug with a given mechanism of action, is a multi-study, collaborative effort between the NCI and many pharmaceutical companies to begin to clarify the significance of molecular alterations in tumors not previously studied.
To examine for individual factors that may predict response to inhibitory repetitive transcranial magnetic stimulation (rTMS) in focal hand dystonia (FHD); to present the method for determining optimal stimulation to increase inhibition in a given patient; and to examine individual responses to prolonged intervention.
These clinical studies suggest that intermediate monocyte frequency may predict response to therapy and side effect profile in RA patients using immunosuppressive therapy.
In addition, there will be recordings of electrical currents in the brain (electroencephalography, or EEG, another safe and non-invasive test) when individuals are processing sounds considered an index of serotonin function, which may predict response to a specific class of antidepressants.
Several tumors harbored mutations that may predict response to investigational agents.
A major clinical need is to identify biomarkers that provide prognostic information regarding BPH progression or that may predict response to treatments, including 5 alpha reductase inhibitors.
Another potentially important use of CTCs for biomarker analysis is detection of oncogenic mutations that may predict response to targeted agents [1].
Examples include PDGFRA (n = 1) and PIK3CA (n = 2), which may predict response to existing drugs (e.g., imatinib or nilotinib) or agents in development (e.g., PI3 kinase inhibitors).
