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Using data from a relapse prevention study of duloxetine treatment for adults with major depressive disorder (MDD), we examined demographic- and illness-related variables to identify factors that may predict relapse of MDD.
To evaluate if WT1 expression may predict relapse after allo-SCT, we analyzed WT1 levels on peripheral blood (PB) and bone marrow (BM) before and after allo-SCT in 24 AML patients with WT1 overexpression at diagnosis.
Indeed, determining the nature, extent, and time course of the attenuated HPA axis response during abstinence may have significant clinical relevance because low levels of basal cortisol and of the ACTH response may predict relapse to alcohol use during early abstinence (Adinoff et al. 1998; Junghanns et al. 2003, 2005; Kiefer et al. 2002).
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The follow-up of BDG and mannan kinetics may also predict relapses.
Different mutations are present in different regions of any given lung cancer, and their pattern may predict patient relapse.
15– 18 Our findings suggest that the expression level of CLCA1 may predict disease relapse and outcomes for patients with CRC.
The current study also suggests that a potential prognostic significance of PI3K signaling may predict early relapse in patients with invasive breast cancers.
In breast cancer, where bone metastases are more frequent, DTCs in the bone marrow may predict metastatic relapse in other organs as well (Braun et al, 2000, 2005).
Although basal CK expression may predict early relapse among nonselected tumours, the clinical outcome of basal tumours has been found to be similar to that of nonbasal ER-negative tumours [ 5].
TGFβ1 has been shown to differentially regulate myeloid leukemia in the BME with suppressive effects on CML leukemia stem cells and proliferative effects on AML stem cells, and plasma-derived exosome content of TGFβ1 from AML blasts may predict AML relapse.
An earlier finding in this population shows that reduced activity in the insula (see sidebar, "Brain Regions and Their Contributions to Behavior") in stimulant addicts during decisionmaking (Paulus et al. 2005) or attention tasks (Clark et al. 2012) may predict subsequent relapse.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com