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We hypothesized that embryo cohort-specific variables describing sibling embryos as a group may predict developmental competence as measured by IVF cycle outcomes and serve to define human embryo phenotypes.
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Using a panel of well-defined human teratogens, biomarkers were identified that may be suited to predict developmental toxicity.
Although ToxCast HTS data and other information may not yet be sufficient to predict developmental toxicity in animals and humans, it is providing unique and valuable mechanistic information on prototypical toxicity pathways such as vascular disruption that could assist in chemical prioritization and further targeted testing.
Already, the group is using its formula to predict developmental rates for aquatic organisms.
Preterm birth is a prime predictor of neonatal complications, mortality, and developmental delay.[ 1, 2] Also, birth weight may predict both short- and long-term adverse outcomes.
In view of the evidence for developmental delay 3 4 and poorer cognitive outcomes 5 6 associated with early growth faltering, one may predict that adverse effects extend to psychosocial development and educational attainment.
Economists may predict dire consequences.
Cynics may predict a partisan circus.
These astrologists may predict the answer.
Creyghton, M. P. et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state.
Creyghton, M.P. et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com