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Gene expression patterns may predict benefit from gemcitabine-containing neoadjuvant therapy.
In addition, IDH mutation status may predict benefit from alkylating agent when combined with MGMT promoter methylation assessment [ 13].
Randomised controlled trials are necessary to assess the efficacy of Seocalcitol with regard to survival, and to identify patient characteristics that may predict benefit from the treatment.
This has implications for the use of anti-VEGF therapy in this setting and should be taken into consideration when designing clinical trials to assess the efficacy of such drugs and biomarkers that may predict benefit.
One way in which to confirm or refute these results and to determine whether certain patient or treatment characteristics may predict benefit from inhaled Nitric Oxide in premature infants is by means of an individual patient data meta-analysis.
Also, it has been suggested that although abnormally elevated pressure at SOM may predict benefit from biliary sphincterotomy in type II and III patients, the reverse may not hold true [ 8] and that a single negative SOM study does not rule out sphincter of Oddi dysfunction [ 17].
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These data suggest that BER expression may predict benefits from endocrine therapy.
Meanwhile, CTCs detected during chemotherapy may indicate that the drug given was not working and may not necessarily predict benefit from a higher dose (which would be toxic) or a different drug.
Our analysis of phase III data from CALGB80303 also identified several markers with significant prognostic importance, as well as markers that may predict for benefit or lack of benefit from bevacizumab.
Here, we sought to identify molecular biomarkers in NSCLC that may predict for benefit from anti-IGF-1R directed therapy.
Co-amplification of Her-2 and TopoIIa may predict anthracycline benefit [ 36, 37].
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