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Redundancy, pleiotropic effects and subtle phenotypes may preclude identification of mutants affecting some processes in screens for phenotypic changes.
Apparent allelic heterogeneity may preclude identification in a standard meta-analysis, but would justify further investigation of independent or dependent signals at loci showing this phenomenon.
Classifying all Asian ethnic groups as a single group greatly obscures the sometimes substantial ethnic differences and may preclude identification of particularly vulnerable subgroups that deserve intensified disease management.
To enable further progress, systems and protocols for isolating and characterising CTCs need to be rigorously defined and standardised, with an analysis of whether all systems identify/isolate the same cells (or indeed all CTCs, since EMT may preclude identification using epithelial markers [ 141, 161- 163]).
Similar(56)
Also, identifying early but existing lung injury on chest radiograph is inherently subjective and requiring recognition of radiographic abnormalities may preclude early identification of some patients, particularly high risk surgical patients.
However, the structural differences that result from the lack of post-translational modifications and possible misfolding of these recombinant proteins may preclude the identification of aptamers that would maintain their binding in a physiological environment.
This value is likely inflated, as ESTs by nature contain variable untranslated regions and other features that may preclude efficient identification of homologs.
Also, the use of BLAST to match signatures to the genome may preclude the identification of single nucleotide mismatches between the sequence and the genome or transcriptome databases.
This design may have precluded identification of other important genes involved in the tubular cell response to albumin exposure (Type II Error).
Similarly, the small sample size contributed to the large confidence intervals around significant point estimates in this study and may have precluded identification of weaker mediation effects.
However, a lack of statistical power may have precluded identification of such a correlation; very few patients had coronary artery dilatation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com