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Highly disparate molecular profiles of spatially separated tumor areas within the same tumor may preclude development of molecularly targeted therapies based on single tumor biopsies.
Rodent Wwox mutants typically exhibit early death, which may preclude development of some tumours, in addition to metabolic disorders, but they are otherwise surprisingly different in their phenotypes (19– 25).
Careful consideration of ways to mitigate the risk to study participants may preclude development of a human challenge model in the short term, but it is hoped that insights from enteric fever challenge studies can benefit ongoing disease surveillance and contribute to the collaborative effort to control invasive Salmonella disease across Africa.
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One advantage of this generic approach may be the ability to predict outcomes in less common cancers where limited data might preclude development of specific models.
The well known sequence requirements of "canonical triplex" formation have been heretofore understood to preclude development of molecular diagnostic methods whereby base pairs in stable heteropolymeric duplex samples may be assayed with base specific resolution using third strand probes.
To so hold would preclude development and fix a city forever in its primitive conditions.
Because they preclude development, national monuments are also critically important for ecological protection.
The low attack rate in the general population may preclude the successful development of a model, even at high challenge dose.
While local innovations have been successful for implementing "starter" streetcar lines, there is a real possibility that these innovations may preclude long-term sustainable development, and regional transit investment.
The developer is concerned that the latest documents from the M.T.A. specifically describe an upscale development, which may preclude a Sears.
Similarly, the contribution of angiogenesis to the development of psoriatic plaques may preclude the use of PHDIs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com