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Arterial invasion constitutes T4b disease, which may preclude curative surgery.
CT scanning can help identify metastatic disease and invasion into adjacent organs that may preclude curative treatment goals.
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Gross obesity, which is increasingly common may not only be the cause of the disease but can preclude curative surgery and in a small number of cases results in suboptimal treatment by brachytherapy alone.
If the intraoperative findings preclude curative resection, patients are exposed to an unnecessary invasive procedure.
Locally advanced tumours that involve major blood vessels and metastatic disease are the most common factors that preclude curative resection.
Pancreatic carcinoma has a poor prognosis, and involvement of major blood vessels and metastatic disease are the most common factors that preclude curative resection [ 1, 15].
The aim of imaging in such patients is to diagnose the local recurrence and confirm the absence of other disease sites that would preclude curative surgery.
The presence of superior mediastinal nodes may preclude surgery for curative intent so CT or MRI may be indicated if there are predictors of mediastinal disease such as lateral nodes or primary tumor greater than 1.5 cm.
Moreover, ARF may preclude optimal cancer treatment by requiring a decrease in chemotherapy dosage or by contraindicating potentially curative treatment.
In addition to hospital mortality, development of an ARF may preclude optimal cancer treatment by requiring a decrease in chemotherapy dosage or by contraindicating potentially curative treatment (e.g., high-dose methotrexate in patients with recently diagnosed Burkitt lymphoma) [ 7].
Security may preclude some of these pleasures.
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