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Together, these data indicate that disturbances to biometal homeostasis may precede detectable clinical signs in CLN6 disease.
There are several possible reasons for this observation: the workers with pain in the present study reported relatively low severity of their myalgia, metabolic alterations may precede detectable alterations in levels of algesics, or peripheral sensitization and other muscle alterations present in TM.
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It is presumed that changes in the circulating miRNA expression pattern represent fingerprints for various diseases [ 28- 30] and may even precede detectable changes of standard diagnostic tools [ 28, 31].
Therefore, the diagnosis of early glaucoma may be difficult: IOP is not necessarily related to ONH damage, structural ONH or RNFL alterations can precede detectable changes by SAP [ 6, 7] or functional deterioration can be present without measurable changes in structural tests currently available [ 8– 10].
Thus, reductions in ONH blood flow detectable by OCT angiography precede detectable visual field damage, suggesting it could be useful in the early detection of glaucoma and the evaluation of glaucoma progression risk.
The finding of a persistent nephrogram may precede the development of oliguria or a detectable increase in SCr, which might warrant a significant change in clinical care.
Overall, these findings suggest that pathophysiological effects of Huntington's disease may precede the development of overt clinical symptoms and detectable cerebral atrophy.
This is the first evidence of a patient with RBD with cardiac sympathetic denervation and a normal DAT-scan, demonstrating that cardiac sympathetic nerve terminals may be impaired in absence of detectable damage in nigrostriatal the cardiac innervation may precede neuronal cell loss in the dopaminergic nigrostriatal system.
Anecdotal evidence may precede the statistics.
The inflammation may precede or follow formation of the clot.
So spotting conditions that may precede attacks is harder.
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