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eNOS-overexpressing endothelial cells may potentially overcome the biochemical loss due to shear induced reduction in endothelial cell coverage on SSDVG.
This discrepancy is difficult to interpret, though may relate to the relative small size of tumours in mouse models compared to patients, where diffusion of the radiotracer may potentially overcome poor delivery by destroyed vasculature.
As lignite has a low calorific value and petroleum coke has low reactivity due to its low number of pores and alkali species, blending the two may potentially overcome their individual drawbacks by combining their advantages (Wang et al. 2004; Wu et al. 2009; Zhan et al. 2011).
Activity trackers may potentially overcome this issue.
Marker-assisted selection (MAS) may potentially overcome this problem.
Therefore, combining VEGF blockade with inhibition of Ang‐2 may potentially overcome resistance to bevacizumab therapy.
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This may be potentially overcome by the use of questionnaires in the clinic which could guide the MDT in recommending a particular treatment plan best suited to the patient.
This may be potentially overcome by the use of a HRE to restrict expression to the hypoxic tumour environment.
Nationally-driven implementation may also potentially overcome the problems associated with silo budgeting as GDFT represents an anaesthetic intervention- thereby adding cost to clinical departments of anaesthesia- to provide financial benefits for surgical services such as decreased hospital length of stay.
However, the benefits of anti-angiogenic therapy can be limited by redundant mechanisms of angiogenesis control, a problem that may potentially be overcome by targeting multiple angiogenic pathways or the use of broad spectrum angiogenic inhibitors [6].
However, recent advances in the use of nanoparticles for systemic siRNA delivery in humans may potentially help overcome this limitation [61].
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