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Since DHA can modulate glial cell activity, it was considered that dietary supplement of DHA may positively modulate the effects of Alzheimer [109].
In addition, there is evidence that colonic probiotic bacteria may positively modulate certain colon microbial enzymes that may play a role in diet-related diseases.
Increasing vitamin D intake may positively modulate the response to antiviral treatment in HCV-infected or HIV/HCV co-infected patients.
Overall, each of the aforementioned genes may positively modulate autophagy under most circumstances, and the cell line used in siRNA screen 2 may simply represent an unusual genetic context in which those genes act as negative modulators of autophagy.
Having found that FoxM1 may positively modulate the stemness in HCT-15 cells and be the primary target mediating their sensitivity to thiostrepton, we dissected the role of this transcription factor in the maintenance of CD44+ subpopulations in two other CRC lines as well as evaluating their response to thiostrepton.
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Specifically, glutamine can positively modulate autophagy through glutaminolysis via the production of ammonia, a positive modulator of autophagy (Table S1I).
Second, linagliptin increases GLP-1 and GIP levels which may provide beneficial cardioprotection; experimental and clinical data suggest that GLP-1 elevation can positively modulate lipid metabolism [ 26], reduce infarct size and improve cardiac function [ 26, 27].
The results herein presented point to the existence of a Notch-mediated mechanism able to positively modulate the expression of adhesion proteins, such as N-cadherin and α9-integrin, which may drive motility and invasiveness in neoplasic cells, thereby permitting cancer progression.
Probiotics are proposed to positively modulate the intestinal epithelial barrier formed by intestinal epithelial cells (IECs) and intercellular junctions.
NGAL seems to positively modulate the activity of MMP-9 [ 9].
In Oryza sativa L., OsSKIPa could positively modulate cell viability and stress tolerance [ 22].
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