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The influence of nepotism in the selection process may pose multiple challenges to the ASHA programme.
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Ceiling effects pose multiple psychometric limitations [ 16].
Unfortunately, amyl nitrites also appear to pose multiple health risks that disproportionately impact MSM.
Furthermore, too many strong RVDs at the N-terminal part of CRD may pose a risk of multiple off-target effects.
CNS IDDs, including classic multiple sclerosis, may pose histopathological challenges.
Basal-bolus regimens comprising of multiple injections may pose a challenge to older patients, so this type of therapy may be suitable only to a small group of well-functioning elderly patients.
β-Glucosyltransferase was shown to exhibit inefficiencies when glucosylating 5hmCpGs when another 5hmC is within 4 bp, 16b which may pose difficulties for sites with multiple 5hmCs in close proximity.
Due to the relatively long duration and multiple components of our study, attrition rates may pose a potential limitation, making it difficult to reach our recruitment goal.
Registered patients will furthermore show variable extent of genetic testing with multiple techniques; in some patients without genetic testing it may pose a difficulty to uncover phenotypic overlaps ("phenocopies") with other polycystic kidney disorders.
An increase in the number of medications may pose a higher risk of hyperpharmacotherapy, and an assessment tool to ensure the safety of patients taking multiple drugs is needed (Feinberg and Simonson 2005).
But polygamy may pose some negative externalities.
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