Exact(2)
It should be noted that during meiosis, chromatin is heavily condensed and this may pose limitations for the transcriptional machinery of the cell.
Nevertheless, both translocational feedbacks (switching back and forth between compartments) and strongly-coupled delayed scenarios (i.e. several delayed reactions compete for the same reactants) may pose limitations in terms of accuracy, if using fixed distributions in the whole simulation timecourse, due to non-negligible effects from time-varying delay distributions.
Similar(58)
The clinical relevance of tolerance has not been established for NSAID gastro-protection as opposed to GERD treatment, but it may pose some limitations for long-term use of H2RAs for NSAID gastro-protection.
When epistasis interactions are involved, then it is likely that simple methods, such as single-locus filters, will not alone be able to provide most optimal results, while in extremely large datasets, wrapper methods may pose computational limitations if combined with complex prediction models.
This issue may pose a limitation on applicability of the Dalhousie dyspnea and perceived exertion scales.
However, the exponential explosion in the size of the markov model as the number of such components increase may pose great limitation in its application at this stage of design.
This may pose a limitation to generate sublines of the desired phenotype, but since the original transgene construct gave very reproducible over-expression, new founders could be readily back-crossed to different inbred mouse strains to generate congenic strains in order to recapitulate the "obese" phenotype on more defined genetic backgrounds.
Focusing on genes measured in all studies may pose a limitation to the proposed analysis.
The use of a single monitoring site for the whole city of Erfurt may pose a limitation to this study.
In the setting for this study, only 25% of caring staff were RNs and this may pose a limitation for the quality of the care.
However, the observation that [C]PIB displays relatively high nonspecific binding in nontarget areas may pose a limitation to its ability to measure discrete changes in amyloid-β load caused by disease progression or drug therapy that lowers amyloid-β.
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