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This is because components of fitness are likely to trade-off against each other, such that any particular component may poorly reflect total fitness.
We concur with W&D that population growth rate is a reasonable metric, however for critically endangered species, changes in short-term stochastic risk of extinction may be a more sensitive and meaningful measure of a CMMB program's success [16] and for many harvested species, simple deterministic growth rates may poorly reflect real population dynamics [17].
The mitotic (M) phase of the cell cycle is relatively short so may poorly reflect overall cell cycle activity.
It has been shown that the relations seen in country level data may poorly reflect the relationships that exist on an individual basis [ 52].
They may underestimate the burden of prior disease (i.e. falsely inflating the estimate of unheralded AMI) and may poorly reflect the timing of initial and subsequent manifestations of disease.
If only a small fraction of the genome is exposed to mutagen, as may be plausible, the observed relationship between average mutation rate and virion survival may poorly reflect the genome-wide tolerance of mutations.
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It has recently been pointed out that standard monolayer cultures may only poorly reflect the in vivo environment of Ewing tumour cells (Lawlor et al, 2002).
In this context, it has been pointed out that standard monolayer cultures may only poorly reflect the in vivo environment of Ewing tumour cells (Lawlor et al, 2002), emphasising the importance of culture conditions on in vitro results and their biological significance.
An important corollary to this is that some transient responses visible in MEG may be poorly reflected in the BOLD changes in fMRI, and therefore we should treat comparisons of results of experiments from the two imaging modalities with caution.
In any case, it must be acknowledged that psychosocial strain at the individual level, such as threats and violence, [ 27] may be poorly reflected by an aggregated measure of exposure as used in this study.
However, reverse genomic approaches also have shortcomings; for example gene deletions poorly reflect natural evolution, the deletion cassettes may affect neighbouring genes (creating false positives) and secondary mutations may have arisen during laboratory manipulations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com