This rapid genes induction implied that sesamin may play role since early of osteoblast differentiation process.
The cellular environment may play a role since apically-expulsed cells will find themselves closer in proximity to the peripodial membrane and will thereby be under the influence of signaling molecules like Dpp expressed by this tissue [32], [33].
Instead, derivation from a single blastomere may play a role, since Geens et al. [11], who succeeded in deriving hESC lines from embryos that were established for the study of early development, obtained a cytogenetically abnormal line.
Secondly, it appears that the species and the strain investigated may play a role, since most of the data showing weight loss have been obtained with subordinate rats or tree shrews and only a few with mice [41] [43].
Among these, three C2/H2 zinc finger-type transcription factors were increased and may play significant roles since two of the genes STZ and RHL41/Zat12 have been found to promote stress tolerance [37], [38], [51].
The fluoride ion may play a role, since many of the observations in rodents overexposed to sulfuryl fluoride are typical of acute fluoride poisoning [ 187].
With a longer follow-up period selection may play a role since patients move away and general practices drop out from the registration.
The lowered presence of Treg cells may play a role since it has been shown that Treg cells can lyse antigen-presenting B cells [ 50].
Medication may play a role, since insomnia is a well-known side-effect of stimulant medication [ 11] and bedtime refusal may be due to a rebound effect when stimulant medication wears off [ 12].
Alternatively, tissue specificity may play a role, since dermal fibroblasts from WS, HGPS, DKC and AT all show premature senescence, and a notable feature of these particular progeroid syndromes is skin ageing.
