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Therefore, A630001G21Rik may play previously unknown role in regulation of Bcl2 expression and apoptosis activity.
PAX genes, similarly to the NOTCH gene family, may play previously unrecognized fundamental roles in balancing proliferation and differentiation signals, two conceptually opposite cellular processes in canonical cancer research.
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As such, VCAM-1 may play a previously unrecognized role in mediating interactions between donor effector T lymphocytes and host epithelial cell targets.
Emerging evidence demonstrates that EF-Tu may play a previously under-appreciated role as a bacterial virulence factor.
Thus, proper sperm chromatin post-meiotic packaging may play a previously unappreciated role in preventing ectopic polar body extrusion and aneuploidy formation during meiosis II.
We speculate that the postulated ectopic synthesis of cartilage ECM may play a previously unreported role in the establishment of osseointegration.
We hypothesize that copper uptake may play a previously uncharacterized role in capsule formation, and is important for the strong phagocytic inhibition evidenced by wild type C. neoformans cells.
In summary, post-meiotic remodeling and repackaging of sperm chromatin may play a previously unappreciated role in orchestrating cytoskeletal assembly but limiting its ability to induce spindle formation during fertilization, thus constituting a protective mechanism to prevent ectopic polar body extrusion and a potential of paternal genome loss during fertilization.
Our results further support the hypothesis that IL-29 may play a previously unrecognized role in the pathogenesis of RA.
Our findings for the peroxisome suggest that this organelle may play a previously unsuspected role in iron metabolism.
These observations suggest that Rab9 may play a previously unappreciated role in the formation of lysosome-related organelles by coordinating the activation and inactivation of Rab32 and Rab38.
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